Ibuprofen-tyrosine (Val-Tyr, Val-Tyr-Val) interactions. Theoretical and experimental studies
Vol. 76 No. 2 (2011), Artykuły
Vol. 76 No. 2 (2011)

Ibuprofen-tyrosine (Val-Tyr, Val-Tyr-Val) interactions. Theoretical and experimental studies

Artykuły
https://doi.org/10.34658/bfs.2011.75.15-26
Published December 31, 2011
Agnieszka Kowalska-Baron
Institute of General Food Chemistry, Faculty of Biotechnology and Food Science, Technical University of Lodz, 90-924 Lodz, Poland
Michaela Brychtova
Faculty of Technology, Tomas Bata University in Zlin, 762 72, Zlín, Czech Republic
Ivana Petrović
Faculty of Food Technology, The University of Josip Juraj Strossmayer, 31000, Osijek, Croatia
Igor Passos Sene
Faculty of Food Engineering, State University of Campinas (UNICAMP), 13035-388, Campinas, Brazil
Paloma Quiñones
Instituto Tecnológico de Durango, Chemical and Biochemical Department, 1803, Victoria de Durango, México
Jana Šogorkova
Institute of Chemical Technology, Faculty of Food and Biochemical Technology, 166 28, Prague, Czech Republic
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Keywords

ibuprofen
hydrogen bonding interactions
PM3 calculations

How to Cite

Kowalska-Baron, A., Brychtova, M., Petrović, I., Sene, I. P., Quiñones, P., & Šogorkova, J. (2011). Ibuprofen-tyrosine (Val-Tyr, Val-Tyr-Val) interactions. Theoretical and experimental studies. Biotechnology and Food Science, 76(2), 15-26. https://doi.org/10.34658/bfs.2011.75.15-26
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Abstract

In this work, the interactions between ibuprofen and tyrosine as well selected tyrosine-containing oligopeptides (Val-Tyr, Val-Tyr-Val) have been studied using both experimental (absorption and fluorescence spectroscopy) and theoretical (the PM3 method) techniques. The experimentally obtained values of association constant together with free Gibbs energy of association for the studied tyrosine-ibuprofen and Val-Tyr-; Val-Tyr-Val-ibuprofen complexes have been determined. The obtained results indicated that the mechanism of action of ibuprofen is most probably based on the hydrogen bonding interaction which involves hydroxyl group of tyrosine

https://doi.org/10.34658/bfs.2011.75.15-26
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